The Problem

Surgical delivery may be the unmeasured variable in your trial

In subretinal therapeutic trials, outcomes may depend not only on the biologic product, patient biology, disease stage, anatomy, and dose, but also on how consistently and precisely the surgical delivery is performed.

Cannula stability, instrument-tip precision, reflux-risk behavior, and procedural consistency may vary across surgeons and sites. These factors are often reviewed subjectively, but rarely quantified as structured trial variables.

When outcomes vary, which of these is responsible?

The therapy

Vector, cell product, potency, mechanism.

Characterized

Patient biology

Disease stage, retinal anatomy, baseline function, individual response.

Characterized

Dose / exposure

Concentration, volume, retention, biologic activity.

Characterized

Surgical technical performance

Precision, smoothness, instability, tremor, reflux-risk behavior.

Quantifiable from video

You cannot model what you do not measure

DexteraAI provides candidate quantitative measures of surgical execution that can be evaluated alongside sponsor-defined procedural, safety, imaging, and clinical endpoints.