The Problem

Surgical delivery may be the unmeasured variable in your trial

In subretinal therapeutic trials, outcomes may depend not only on the biologic product, patient biology, disease stage, anatomy, and dose, but also on the characteristics of the surgical delivery itself.

Cannula stability, instrument-tip precision, reflux-retinotomy behavior, and delivery consistency may vary across surgeons, sites, and cases. These factors are often reviewed subjectively, but rarely quantified as structured trial variables.

When outcomes vary, which of these contributed?

The therapy

Vector, cell product, potency, mechanism.

Characterized

Patient biology

Disease stage, retinal anatomy, baseline function, individual response.

Characterized

Dose / exposure

Concentration, volume, retention, biologic activity.

Characterized

Technical delivery

Precision, smoothness, instability, tremor, reflux-retinotomy behavior.

Quantifiable from video

You cannot model what you do not measure

DexteraAI provides candidate quantitative measures of subretinal delivery that can be evaluated alongside sponsor-defined procedural, safety, imaging, and clinical endpoints.